Montelukast-associated Churg-Strauss syndrome.
نویسندگان
چکیده
A 68-year-old asthmatic presented markedly unwell with arthralgia, mononeuritis multiplex, peripheral neuropathy, and eosinophilia. His past medical history included perennial rhinitis, and nasal polyps. Three months prior to admission his prednisolone was stopped and Montelukast was started. The diagnosis of Montelukast-associated Churg-Strauss syndrome was made. The drug was stopped and steroids started with general improvement and reduction of eosinophilia; however, the neurological deficit persisted.
منابع مشابه
Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma.
STUDY OBJECTIVES We previously reported eight patients who developed Churg-Strauss syndrome in association with zafirlukast treatment for asthma and postulated that the syndrome resulted from unmasking of a previously existing condition due to corticosteroid withdrawal and not from a direct drug effect. The availability of montelukast, a new leukotriene receptor antagonist with a different mole...
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l eukotriene receptor antagonists have been used successfully for asthma treatment. These drugs could induce eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome (CSS), in patients who are prone to develop autoimmune diseases [1] One of the most important adjuvants responsible for developing ASIA (autoimmune/ inflammatory syndrome induced by adjuvants...
متن کاملPulmonary eosinophilia associated with montelukast.
Antileukotriene drugs are new therapeutic agents that have recently been approved for the treatment of asthma. Several cases of eosinophilic conditions including Churg-Strauss syndrome have been reported to be associated with zafirlukast, a cysteinyl leukotriene type 1 receptor antagonist. So far no other leukotriene modifier has been associated with the syndrome. The case history is presented ...
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ورودعنوان ژورنال:
- Age and ageing
دوره 32 5 شماره
صفحات -
تاریخ انتشار 2003